Scientific Opinion on the substantiation of health claims related to Angelica
sinensis (Oliv.) Diels. and maintenance of joints (ID 2392) and oxygen
transport (ID 3845) pursuant to Article 13(1) of Regulation (EC) No
1924/2006[sup]1[/sup]
EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA)2
European Food Safety Authority (EFSA), Parma, Italy
1. Charakterystyka żywności / składnika
The food constituent that is the subject of the health claims is Angelica sinensis (Oliv.) Diels.. The characterisation of Angelica sinensis (Oliv.) Diels. is performed by comparing data provided as conditions of use to information extracted from standard reference textbooks (see Table 2 below and Appendix C for list of standard reference textbooks used for the characterisation).
Table 2. Information on Angelica sinensis (Oliv.) Diels. from standard reference textbooks and the information provided as conditions of use.
ID Scientific name Part used
Nature of the
preparation Conditions of use
Text-
book
Angelica sinensis
(OLIV.) DIELS = A.
anomala AVE-
LALL var. sinensis
= A. fallax BOISS =
A. polymorpha var.
sinensis OLIV.
Apiaceae
Root Dried root;
powder;
essential oil;
tincture;
extract;
infusion
Root: 3-15 g/day and equivalent
preparations
Dried standardised extract (0.8-1.1%
ligustilide): 200 mg, 2 times/day
Dried standardised extract ((7:1), 0.1%
ferulic acid): 350 mg, 2 times/day
Tincture (1:5): 5 mL, 3 times/day
Infusion (root): 5 g/150 mL, 3 times/day
2392 Angelica sinensis
(OLIV.) DIELS
(Angelica)
Root Not specified.
Note: it is
assumed to be
the dried form
Root: 180-360 mg / Used as part of a
multibotanical combination.
Note: the daily amount is not specified
3845 Angelica sinensis
(OLIV.) DIELS
(Common Name :
Angelica)
Root Dried root;
powder
Preparation: an amount equivalent to 3-15 g
of dried root or 3-6 g of powdered root/day.
ID 2392:
The daily amount is not specified. The Panel notes that the consolidated list contains insufficient information to allow a characterisation of Angelica sinensis (Oliv.) Diels..
The Panel notes that there is no information on the other components of the multibotanical combination.
The Panel considers that the food constituent, Angelica sinensis (Oliv.) Diels., which is the subject of the health claim, has not been sufficiently characterised.
ID 3845:
The Panel considers that the food constituent, Angelica sinensis (Oliv.) Diels., which is the subject of the health claim, has been sufficiently characterised with the following conditions of use: an amount equivalent to 3-15 g of dried root or 3-6 g of powdered root/day.
2. Znaczenie oświadczenia dla zdrowia człowieka
2.1. Utrzymanie prawidłowego stanu stawów (ID 2392)
The claimed effect is “metabolism in joints”. The Panel assumes that the target population is the general population.
In the context of the proposed wordings the Panel assumes that the claimed effect refers to maintenance of normal joints.
The Panel considers that maintenance of normal joints is beneficial to human health.
2.2. Transport tlenu (ID 3845)
The claimed effect is “blood system”. The Panel assumes that the target population is the general population.
The claimed effect “blood system” is not sufficiently defined. However, from the proposed wordings the Panel assumes that the claimed effect refers to oxygen transport.
The Panel considers that normal oxygen transport is beneficial to human health.
3. Naukowe uzasadnienia wpływu na zdrowie człowieka
3.1. Utrzymanie prawidłowego stanu stawów (ID 2392)
One reference was cited to substantiate the claimed effect. This reference was a monograph in which some effects of Angelica sinensis are mentioned but these were not related to the maintenance of normal joints. The Panel notes that the reference cited did not provide any scientific data that could be used to substantiate the claimed effect.
The Panel concludes that a cause and effect relationship has not been established between the consumption of Angelica sinensis (Oliv.) Diels. and maintenance of normal joints.
3.2. Transport tlenu (ID 3845)
Four references were cited to substantiate the claimed effect. Two references were monographs in which the claimed effect is stated. Two were animal studies; one investigated the antiproliferative effect of a compound isolated from Angelica sinensis (Oliv.) Diels. on rat vascular muscle cells and one studied the effect of the same compound on the vasorelaxation of rat thoracic aorta. The Panel notes that these references did not provide any scientific data that could be used to substantiate the claimed effect.
The Panel concludes that a cause and effect relationship has not been established between the consumption of Angelica sinensis (Oliv.) Diels. and normal oxygen transport.
