ID 816 - Częściowo hydrolizowana guma guar

PL: Częściowo hydrolizowana guma guar
EN: Partially Hydrolysed Guar Gum (PHGG)
Pdf: partially hydrolysed guar gum

Oświadczenie (2)

1. Charakterystyka żywności / składnika

The food that is subject of the health claim is partially hydrolysed guar gum (PHGG), which is produced from guar gum by digestion with D-mannanase. It has a lower viscosity and a molecular weight of 20 kDa. PHGG is not naturally occurring in foods and is usually consumed in the form of food supplements. PHGG can be measured in foods by established methods.
The Panel considers that the food constituent, partially hydrolysed guar gum, which is the subject of the health claims is sufficiently characterised.

2.3. Utrzymanie prawidłowego stężenia trójglicerydów we krwi (ID 793, 816)

The claimed effects are “lipid management” and “heart health/cholesterol maintenance”. The Panel assumes that the target population is the general population.
In the context of the proposed wordings, the Panel notes that the claimed effect relates to maintenance of normal (fasting) blood concentrations of triglycerides and of normal blood cholesterol concentrations. The latter is addressed in section 2.4.
Triglycerides in plasma are either derived from dietary fats or synthesised in the body from other energy sources like carbohydrates. In fasting conditions, serum triglycerides are mainly transported in very-low-density lipoproteins (VLDL) synthesised in the liver. Excess calorie intake with a meal is converted to triglyceride and transported to the adipose tissue for storage. Hormones regulate the release of triglycerides from adipose tissue in order to meet energy needs between meals. Normal values for blood concentrations of triglycerides have been defined.
The Panel considers that maintenance of normal (fasting) blood concentrations of triglycerides may be a beneficial physiological effect.

2.4. Utrzymanie prawidłowego stężenia cholesterolu we krwi (ID 793, 816)

The claimed effects are “lipid management” and “heart health/cholesterol maintenance”. The Panel assumes that the target population is the general population.
In the context of the proposed wordings, the Panel notes that the claimed effect relates to maintenance of normal (fasting) blood concentrations of triglycerides and of normal blood cholesterol concentrations. The former is addressed in section 2.3.
Low-density lipoproteins (LDL) carry cholesterol from the liver to peripheral tissues, including the arteries. Elevated LDL-cholesterol, by convention >160 mg/dL, may compromise the normal structure and function of the arteries.
The Panel considers that maintaining normal blood cholesterol concentrations is a beneficial physiological effect.

3.3. Utrzymanie prawidłowego stężenia trójglicerydów we krwi (ID 793, 816)

The references provided included studies on the effects of food/food constituents other than PHGG (e.g., guar gum), on health outcomes other than fasting concentrations of triglycerides (e.g. faecal output, acute post-prandial concentrations of triglycerides). The Panel considers that no scientific conclusions can be drawn from these references for the substantiation of the claim.
Only two of the references provided directly assessed the effects of PHGG on fasting serum concentrations of triglycerides in humans (Takahashi et al., 1993; Yamatoya et al., 1997). In the study by Takahashi et al. (1993), a very high dose of PHGG (108 g per day) was administered to eight male subjects after a control, PHGG-free diet, for four weeks. The Panel notes the small number of subjects, the absence of a control group, and that the dose of PHGG used is several times higher than the amount proposed in the conditions of use to obtain the claimed effect. In the study by Yamatoya et
al. (1997), 15 women with total cholesterol concentrations 190 mg/dL (4.91 mmol/L) were assigned to consume either 5 g per day (n=9) or 15 g per day (n=6) of PHGG for two consecutive weeks. The Panel notes the small number of subjects, the absence of a control group, and the short period of the intervention.
The Panel considers that no conclusions can be drawn from these small, non-controlled studies for the substantiation of the claimed effect.
The Panel concludes that a cause and effect relationship has not been established between the consumption of PHGG and maintenance of normal (fasting) blood concentrations of triglycerides.

3.4. Utrzymanie prawidłowego stężenia cholesterolu we krwi (ID 793, 816)

The references provided included studies on the effects of food/food constituents other than PHGG (e.g., guar gum) on health outcomes other than blood cholesterol (e.g., faecal output, post-prandial concentrations of triglycerides). The Panel considers that no scientific conclusions can be drawn from these references for the substantiation of the claim.
Only two of the references provided directly assessed the effects of PHGG on total serum cholesterol concentrations in humans (Takahashi et al., 1993; Yamatoya et al., 1997). In the study by Takahashi et al. (1993), a very high dose of PHGG (108 g per day) was administered to eight male subjects after a control, PHGG-free diet, for four weeks. The Panel notes the small number of subjects, the absence of a control group, and that the dose of PHGG used is several times higher than the amount proposed in the conditions of use to obtain the claimed effect. In the study by Yamatoya et al. (1997),
15 women with total cholesterol concentrations 190 mg/dL (4.91 mmol/L) were assigned to consume either 5 g per day (n=9) or 15 g per day (n=6) of PHGG for two consecutive weeks. The Panel notes the small number of subjects, the absence of a control group, and the short period of the intervention.
The Panel considers that no conclusions can be drawn from these small, non-controlled studies for the substantiation of the claimed effect.
The Panel concludes that a cause and effect relationship has not been established between the consumption of PHGG and maintenance of normal blood cholesterol concentrations at the proposed conditions of use.

Warunki i możliwe ograniczenia stosowania oświadczenia

AI for total fiber (IOM): 26-38 g/day (ideally 8.5-12.5 g/day soluble fiber)