ID 72 - Witamina B6

PL: Witamina B6
EN: Vitamin B6
Pdf: vitamin B6

Oświadczenie (4)

Oświadczenie (2)

1. Charakterystyka żywności / składnika

The food constituent that is the subject of the health claims is vitamin B6, which is a group of compounds comprising three free forms, pyridoxine, pyridoxal, pyridoxamine, and their 5'-phosphates derivatives (PNP, PLP and PMP). Vitamin B6 occurs naturally in foods, mainly as pyridoxal phosphate (animals), pyridoxine beta-glucoside (plants), and some pyridoxyl peptides (processed foods), with varied bioavailability as vitamin B6. Vitamin B6 is a well recognised nutrient and is measurable in foods by established methods.
Vitamin B6 it is authorised for addition to foods (Annex I of the Regulation (EC) No 1925/20064 and Annex I of Directive 2002/46/EC5). This evaluation applies to vitamin B6 naturally present in foods and those forms authorised for addition to foods (Annex II of the Regulation (EC) No 1925/2006, and Annex II of Directive 2002/46/EC).
The Panel considers that the food constituent, vitamin B6, which is the subject of the health claims, is sufficiently characterised.

2.3. Tworzenie erytrocytów (czerwonych krwinek) (ID 67, 72, 186)

The claimed effects are “transport and metabolism of iron”, “blood health”, “vitamin B6 helps the body effective use iron”. The Panel assumes that the target population is the general population.
In the context of the proposed wordings, the Panel notes that the claimed effect relates to the formation of normal red blood cells.
The Panel considers that normal red blood cell formation is beneficial to human health.

3. Naukowe uzasadnienia wpływu na zdrowie człowieka

Vitamin B6 functions as a coenzyme in a variety of enzymatic reactions in the metabolism of amino acids, one-carbon units, lipids, the pathways of gluconeogenesis, haem, and neurotransmitter biosynthesis (McCormick, 2006; Mackey, 2006).

3.3. Tworzenie erytrocytów (czerwonych krwinek) (ID 67, 72, 186)

Vitamin B6 plays an important role in haem biosynthesis in the form of PLP. The first enzyme and committed step in haem biosynthesis, aminolevulinate synthase (ALAS), uses PLP as a coenzyme. ALAS catalyses the condensation of succinyl coenzyme A and glycine to form δ-aminolevulinate, which is the precursor for the porphyrin ring. Chronic vitamin B6 deficiency can cause microcytic, hypochromic anaemia in which the haemoglobin concentration of erythrocytes is reduced. Sideroblastic anaemia is an inherited form of ALAS deficiency which can often be successfully treated with pyridoxine supplementation (Mackey et al., 2006; IoM, 2000). Pyridoxal and pyridoxal phosphate also bind to haemoglobin increasing the oxygen-binding capacity, and preventing sickling in sickle-cell haemoglobin (EVM, 2002).
The Panel concludes that a cause and effect relationship has been established between the dietary intake of vitamin B6 and normal red blood cell formation. However, the evidence provided does not establish that inadequate intake of vitamin B6 leading to impaired red blood cell formation occurs in the general EU population.

4.3. Tworzenie erytrocytów (czerwonych krwinek) (ID 67, 72, 186)

The Panel considers that the following wording reflects the scientific evidence: “Vitamin B6 contributes to normal red blood cell formation”.

5. Warunki i możliwe ograniczenia stosowania oświadczenia

The Panel considers that in order to bear the claims a food should be at least a source of vitamin B6 as per Annex to Regulation (EC) No 1924/2006. Such amounts can be easily consumed as part of a balanced diet. The target population is the general population. Tolerable Upper Intake Levels (UL) have been established for vitamin B6 in children, adolescents and adults (SCF, 2000).

Warunki i możliwe ograniczenia stosowania oświadczenia

Source of / 15% of RDA per 100 g Agency guidance for supplements is that products containing >10mg of vitamin B6 should carry the label advisory statement "long term intakes of this amount of vitamin B6 may lead to mild tingling and numbness"