ID 69 - Witamina B6

PL: Witamina B6
EN: Vitamin B6
Pdf: vitamin B6

Oświadczenie (4)

Oświadczenie (2)

1. Charakterystyka żywności / składnika

The food constituent that is the subject of the health claims is vitamin B6, which is a group of compounds comprising three free forms, pyridoxine, pyridoxal, pyridoxamine, and their 5'-phosphates derivatives (PNP, PLP and PMP). Vitamin B6 occurs naturally in foods, mainly as pyridoxal phosphate (animals), pyridoxine beta-glucoside (plants), and some pyridoxyl peptides (processed foods), with varied bioavailability as vitamin B6. Vitamin B6 is a well recognised nutrient and is measurable in foods by established methods.
Vitamin B6 it is authorised for addition to foods (Annex I of the Regulation (EC) No 1925/20064 and Annex I of Directive 2002/46/EC5). This evaluation applies to vitamin B6 naturally present in foods and those forms authorised for addition to foods (Annex II of the Regulation (EC) No 1925/2006, and Annex II of Directive 2002/46/EC).
The Panel considers that the food constituent, vitamin B6, which is the subject of the health claims, is sufficiently characterised.

2.5. Regulacja aktywności hormonalnej (ID 69)

The claimed effect is “essential co-factor in fatty acid metabolism that impacts upon hormonal health”. The Panel assumes that the target population is the general population.
The Panel notes that the claimed effect has not been sufficiently defined in the evidence provided. The Panel assumes that the claimed effect relates to the regulation of hormonal activity.
The Panel considers that regulation of hormonal activity is beneficial to human health.

3. Naukowe uzasadnienia wpływu na zdrowie człowieka

Vitamin B6 functions as a coenzyme in a variety of enzymatic reactions in the metabolism of amino acids, one-carbon units, lipids, the pathways of gluconeogenesis, haem, and neurotransmitter biosynthesis (McCormick, 2006; Mackey, 2006).

3.5. Regulacja aktywności hormonalnej (ID 69)

Vitamin B6 in the form of pyridoxal phosphate (PLP) has a role in controlling the action of hormones that act by binding to a nuclear receptor protein and modulating gene expression. Such hormones include androgens, oestrogens, progesterone, glucocorticoids, and thyroid hormone. PLP reacts with a lysine residue in the receptor protein and displaces the hormone-receptor complex from DNA binding, so terminating the hormone action (Bender, 2005).
The Panel concludes that a cause and effect relationship has been established between the dietary intake of vitamin B6 and regulation of hormonal activity. However, the evidence provided does not establish that inadequate intake of vitamin B6 leading to impaired regulation of hormonal activity occurs in the general EU population.

4.5. Regulacja aktywności hormonalnej (ID 69)

The Panel considers that the following wording reflects the scientific evidence: “Vitamin B6 contributes to the regulation of hormonal activity”.

5. Warunki i możliwe ograniczenia stosowania oświadczenia

The Panel considers that in order to bear the claims a food should be at least a source of vitamin B6 as per Annex to Regulation (EC) No 1924/2006. Such amounts can be easily consumed as part of a balanced diet. The target population is the general population. Tolerable Upper Intake Levels (UL) have been established for vitamin B6 in children, adolescents and adults (SCF, 2000).

Warunki i możliwe ograniczenia stosowania oświadczenia

The product must contain no less than 15% RDA Long term intakes of over 10mg of vitamin B6 per day may lead to mild tingling and numbness.