ID 4683 -
Arginina
PL: Arginina
EN: Arginin
Pdf: L-arginine
Oświadczenie (4)
- Arginina przyczynia się do prawidłowego usuwania amoniaku z organizmu
Oświadczenie (2)
- ureogenesis poprzez zwiększenie klirensu amoniaku w organizmie
1. Charakterystyka żywności / składnika
The food constituent that is the subject of the health claims is L-arginine.
Arginine is an alpha-amino acid present in foods from animal and vegetable origin. The L-form is the most commonly found form in nature and in food supplements. L-arginine is also known as (S)-2- amino-5-guanidinopentanoic acid and (S)-2-amino-5-[(aminoiminomethyl)amino] pentanoic acid. The terms L-arginine and arginine are frequently used interchangeably. The content of L-arginine in foods can be measured by established methods.
Arginine is a conditionally indispensable amino acid provided by mixed dietary protein intakes from different sources. Arginine can also be consumed in the form of food supplements as L-arginine.
The Panel considers that the food constituent, L-arginine, which is the subject of the health claims, is sufficiently characterised.
2.11. Utrzymanie prawidłowego wydalania amoniaku (ID 4683)
The claimed effect is “ureogenesis by increasing ammonia clearance in the body”. The Panel assumes that the target population is the general population.
In the context of the proposed wordings, the Panel assumes that the claimed effect refers to the maintenance of normal ammonia clearance in the body.
The Panel considers that maintenance of normal ammonia clearance is a beneficial physiological effect.
3.7. Utrzymanie prawidłowego wydalania amoniaku (ID 4683)
Arginine participates in the detoxification of ammonia via the urea cycle, which takes place in the liver. Arginine may be obtained from the diet or from endogenous synthesis, and dietary arginine contributes to the claimed effect.
The references provided for the scientific substantiation of the claim included a monograph, a general review, two in vitro experiments on the control of the urea cycle by factors other than arginine, and one animal study demonstrating the synthesis of urea from arginine and uric acid in the kidney of the frog. The Panel considers that no conclusions can be drawn from these studies for the scientific substantiation of the claimed effect.
No references were provided which addressed the effects of arginine on ammonia clearance.
The Panel concludes that a cause and effect relationship has been established between the consumption of L-arginine in a protein adequate diet and maintenance of normal ammonia clearance. However, no evidence has been provided that the protein supply in the diet of the European population is not sufficient to fulfil this function of the amino acid.
4.1. Utrzymanie prawidłowego wydalania amoniaku (ID 4683)
The Panel considers that the following wording reflects the scientific evidence: “arginine contributes to the maintenance of normal ammonia clearance”.
5.1. Utrzymanie prawidłowego wydalania amoniaku (ID 4683)
The Panel considers that no conditions of use can be defined for L-arginine.
Warunki i możliwe ograniczenia stosowania oświadczenia
