ID 4628 - Pędy psianki słodkogórz, ziele dymnicy lekarskiej, kora wiązu pospolitego, korzeń łopianu większego, korzeń szczwiu, sarsaparilla

PL: Pędy psianki słodkogórz, ziele dymnicy lekarskiej, kora wiązu pospolitego, korzeń łopianu większego, korzeń szczwiu, sarsaparilla
EN: Solanum dulcamara stipes, Fumaria officinalis herba, Ulmus minor cortex, Arctium lappa radix, Rumex Patienta radix, Smilax sarsaparilla radix (bitter nightshade steam, fumitory herbs, field elm bark, burdock root, patience root, smilax root)
Pdf:

Oświadczenie (2)

1.1. Przemiany substancji ksenobiotycznych (oczyszczanie organizmu, detoksykacja) (ID 1378, 2388, 2401, 3900, 3942, 4039, 4510, 4513, 4544, 4628, 4639)

The claimed effects are “purification”, “purifying/detoxifying”, “urinary elimination”, “depurative, detoxificant”, “detoxification”, “blood health”, “supports the natural mechanism for body's purification”, “elimination and detox”, and “favours toxin elimination”. The Panel assumes that the target population is the general population.
In the context of the proposed wordings and/or the clarifications provided by Member States, the Panel assumes that the claimed effect relates to the biotransformation of xenobiotic substances.
Enzymatic biotransformation reactions of xenobiotic substances after absorption involve Phase I and Phase II biotransformation reactions, which usually work together in a sequential manner to convert xenobiotics into more readily excretable metabolites (Yu, 2005; Buhler and Williams, 1988). Phase I biotransformation reactions include oxidation, reduction, and hydrolysis, while Phase II biotransformation consists essentially of conjugation reactions (Yu, 2005). Whereas biotransformation reactions normally result in detoxification, some chemicals may also be enzymatically converted to highly reactive, electrophilic metabolites which may induce cytotoxic, teratogenic, mutagenic or carcinogenic effects through reaction with various cellular constituents (Buhler and Williams, 1988).
The Panel notes that from the proposed wordings or the clarifications provided by Member States it could not be established which xenobiotic substance or which biotransformation reaction related to the elimination of xenobiotic substances is the target for the claim.
In the absence of such information, the Panel considers that the claimed effect is general and non- specific and does not refer to any specific health claim as required by Regulation (EC) No 1924/2006.

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