ID 4283 - Witamina B6

PL: Witamina B6
EN: Vitamin B6
Pdf: vitamin B6

Oświadczenie (4)

Oświadczenie (2)

1. Charakterystyka żywności / składnika

The food constituent that is the subject of the health claims is vitamin B6, which is a group of compounds comprising three free forms, pyridoxine, pyridoxal, pyridoxamine, and their 5'-phosphates derivatives (PNP, PLP and PMP). Vitamin B6 occurs naturally in foods, mainly as pyridoxal phosphate (animals), pyridoxine beta-glucoside (plants) and some pyridoxyl peptides (processed foods). Vitamin B6 is a well recognised nutrient and is measurable in foods by established methods.
Vitamin B6 is authorised for addition to foods (Annex I of the Regulation (EC) No 1925/20066 and Annex I of Directive 2002/46/EC7). This evaluation applies to vitamin B6 naturally present in foods and those forms authorised for addition to foods (Annex II of the Regulation (EC) No 1925/2006, and Annex II of Directive 2002/46/EC).
The Panel considers that the food constituent, vitamin B6, which is the subject of the health claims is sufficiently characterised.

2.10. Udział w prawidłowej syntezie cysteiny (ID 4283)

The claimed effect is “cystine synthesis and incorporation in keratin”. The Panel assumes that the target population is the general population.
The Panel assumes that the claimed effect relates to the synthesis of cysteine. Cysteine is a significant determinant of the tertiary structure of many proteins through a role in the formation of disulfide bonds within and between protein molecules.
The Panel considers that contribution to normal cysteine synthesis is a beneficial physiological effect.

3. Naukowe uzasadnienia wpływu na zdrowie człowieka

Vitamin B6 functions as a coenzyme in a variety of enzymatic reactions in the metabolism of amino acids, one-carbon units, lipids, the pathways of gluconeogenesis, haem, and neurotransmitter biosynthesis (McCormick, 2006; Mackey et al., 2006).

3.10. Udział w prawidłowej syntezie cysteiny (ID 4283)

The SH group in cysteine derives from methionine whilst the carbon skeleton comes from serine. Both the synthesis of cystathionine from homocysteine and serine and the splitting of cystathionine to release cysteine are catalysed by PLP dependent enzymes.
The Panel concludes that a cause and effect relationship has been established between the dietary intake of vitamin B6 and contribution to normal cysteine synthesis.

4.5. Udział w prawidłowej syntezie cysteiny (ID 4283)

The Panel considers that the following wording reflects the scientific evidence: “Vitamin B6 contributes to normal cysteine synthesis”.

5. Warunki i możliwe ograniczenia stosowania oświadczenia

The Panel considers that in order to bear the claims a food should be at least a source of vitamin B6 as per Annex to Regulation (EC) No 1924/2006. Such amounts can be easily consumed as part of a balanced diet. The target population is the general population. Tolerable Upper Intake Levels (ULs) have been established for vitamin B6 in children, adolescents and adults (SCF, 2000).

Warunki i możliwe ograniczenia stosowania oświadczenia