ID 404 - Mangan

PL: Mangan
EN: Manganese
Pdf: manganese

Oświadczenie (4)

Oświadczenie (2)

1. Charakterystyka żywności / składnika

The food constituent that is the subject of the health claims is manganese, which is a well recognised nutrient and is measurable in foods by established methods.
Manganese occurs naturally in foods and is authorised for addition to foods (Annex I of Regulation (EC) No 1925/20066 and Annex I of Directive 2002/46/EC7). This evaluation applies to manganese naturally present in foods and those forms authorised for addition to foods (Annex II of Regulation (EC) No 1925/2006 and Annex II of Directive 2002/46/EC).
The Panel considers that the food constituent, manganese, which is the subject of the health claims, is sufficiently characterised.

2.2. Udział w prawidłowym tworzeniu tkanki łącznej (ID 404)

The claimed effect is “role of manganese within formation of tissue”. The Panel assumes that the target population is the general population.
In the context of the proposed wording, the Panel assumes that the claimed effect refers to the normal formation of connective tissue, including connective tissue in cartilage and bone.
The Panel considers that contribution to normal formation of connective tissue is a beneficial physiological effect.

3.2. Udział w prawidłowym tworzeniu tkanki łącznej (ID 404)

Manganese is essential as a cofactor for the metalloenzymes superoxide dismutase (SOD), xanthine oxidase, arginase, galactosyltransferase and pyruvate carboxylase. Manganese also activates a number of other enzymes such as various decarboxylases, hydrolases, kinases and transferases, for example glycosyltranferases, and glutamine synthetase. Manganese is not essential for the activity of most of these enzyme systems, which can also be activated by other metals, with the exception of glycosyltransferases (JHCI, 2003; Buchman, 2006). Manganese deficiency interferes with normal skeletal development in various animal species (Combs et al., 1942; Leach and Muenster, 1962; Tsai and Everson, 1967).
Glycosyltranferases and xylosyltransferases are important for proteoglycan synthesis and thus formation of connective tissue, including connective tissue in bone and cartilage, and these enzymes are sensitive to manganese intake and status in animals (JHCI, 2003; IoM, 2000; Buchman, 2006). The very few cases of manganese deficiency in humans have been induced in experimental conditions (Buchman, 2006).
The Panel concludes that a cause and effect relationship has been established between the dietary intake of manganese and contribution to normal formation of connective tissue. However, the
evidence provided does not establish that inadequate intake of manganese leading to impaired formation of connective tissue occurs in the general EU population.

4.1. Udział w prawidłowym tworzeniu tkanki łącznej (ID 404)

The Panel considers that the following wording reflects the scientific evidence: “Manganese contributes to the normal formation of connective tissue”.

5. Warunki i możliwe ograniczenia stosowania oświadczenia

The Panel considers that in order to bear the claim a food should be at least a source of manganese as per Annex to Regulation (EC) No 1924/2006. Such amounts can be easily consumed as part of a balanced diet. The target population is the general population. Although adverse health effects of excess intake of manganese have been reported, Tolerable Upper Intake Levels (UL) have not been established owing to lack of data on dose response (SCF, 2000).

Warunki i możliwe ograniczenia stosowania oświadczenia

yes