ID 360 -
Cynk
PL: Cynk
EN: Zink
Pdf: zinc
Oświadczenie (4)
- Cynk przyczynia się do prawidłowego metabolizmu kwasowo-zasadowego
Oświadczenie (2)
- metabolizm kwasowo-zasadowej
1. Charakterystyka żywności / składnika
The food constituent that is the subject of the claims is zinc, which is a well recognized nutrient and is measurable in foods by established methods. Zinc occurs naturally in foods and is authorised for addition to foods (Annex I of the Regulation (EC) No 1925/20064 and Annex I of Directive 2002/46/EC5). This evaluation applies to zinc naturally present in foods and those forms authorised for addition to foods (Annex II of the Regulation (EC) No 1925/2006 and Annex II of Directive 2002/46/EC).
The Panel considers that the food constituent, zinc, which is the subject of the health claims, is sufficiently characterised.
2.14. Metabolizm kwasowo-zasadowy (ID 360)
The claimed effect is “acid-base metabolism”. The Panel assumes that the target population is the general population.
The Panel considers that normal acid-base metabolism is beneficial to human health.
3. Naukowe uzasadnienia wpływu na zdrowie człowieka -
Zinc is present in all tissues. It has essential structural, regulatory or catalytic roles in many enzymes. It maintains the configuration of a number of non-enzymatic proteins such as pre-secretory granules of insulin, some mammalian gene transcription proteins and thymulin. It facilitates hormone and receptor binding at membrane and nuclear levels, and it may maintain integrity of biomembranes. Consequently zinc participates in gene expression and in the mechanisms and control of major metabolic pathways involving proteins, carbohydrates, nucleic acids and lipids (SCF, 1993; DoH, 1991). Human zinc deficiency symptoms include retarded growth, depressed immune function, skin lesions, skeletal abnormalities, impaired reproductive ability and behavioural abnormalities such as changes in mood, loss of affect and emotional lability, anorexia, dysfunction of smell and taste, irritability and depression (SCF, 2003; EVM, 2002, Cousins, 2006).
3.13. Metabolizm kwasowo-zasadowy (ID 360)
Zinc has essential structural, regulatory or catalytic roles in many enzymes. Carbonic anhydrase, is a zinc metalloenzyme, where zinc is a direct participant in the catalytic function.
Blood and extracellular fluid pH are also tightly regulated by the presence of buffer systems which attenuate changes as a consequence of acid load mainly from cellular metabolism or the ingestion of acids in the diet. The principal buffer system is based on bicarbonate (HCO3-). In blood, the major product of oxidative metabolism, CO2, reacts with water in the presence of carbonic anhydrase to form carbonic acid (H2CO3) which is relatively unstable and tends to dissociate and generate H+ and HCO3-. In vivo studies have shown that dietary zinc deficiency significantly reduces red blood cell carbonic anhydrase activity (Freake, 2006; King and Cousins, 2006).
The Panel concludes that a cause and effect relationship has been established between the dietary intake of zinc and acid-base metabolism. However, the evidence provided does not establish that inadequate intake of zinc leading to impaired acid-base metabolism occurs in the general EU population.
4.8. Metabolizm kwasowo-zasadowy (ID 360)
The Panel considers that the following wording reflects the scientific evidence: “Zinc contributes to normal acid-base metabolism”.
5. Warunki i możliwe ograniczenia stosowania oświadczenia
The Panel considers that in order to bear the claim a food should be at least a source of zinc as per Annex to Regulation (EC) No 1924/2006. The target population is the general population. Such amounts can be easily consumed as part of a balanced diet. Tolerable Upper Intake Levels (UL) have been established for zinc as 25 mg/day in adults and to pregnant and lactating woman. For children and adolescents UL was established as 7 mg/day for 1-3 years, 10 mg/day for 4-6 years, 13 mg/day for 7-10 years, 18 mg/day for 11-14 years and 22 mg/day for 15-17 years (SCF 2003).
Warunki i możliwe ograniczenia stosowania oświadczenia
Must meet minimum requirements for use of the claim "source of [name of vitamin/s] and/or [name of mineral/s]" as per Annex to Regulation 1924/2006.
Agency guidance for supplements is that products containing >25 mg of zinc should carry the label advisory statement "Long term intake [of this amount of zinc] may lead to anaemia"