ID 341 -
Molibden
PL: Molibden
EN: Molybdenum
Pdf: molybdenum
1. Charakterystyka żywności / składnika
The food constituent that is the subject of the claims is molybdenum, which is a well recognised nutrient and is measurable in foods by established methods. Molybdenum occurs naturally in foods and is authorised for addition to foods (Annex I of the Regulation (EC) No 1925/20066 and Annex I of Directive 2002/46/EC7). This evaluation applies to molybdenum naturally present in foods and those forms authorised for addition to foods (Annex II of the Regulation (EC) No 1925/2006 and Annex II of Directive 2002/46/EC).
The Panel considers that the food constituent, molybdenum, which is the subject of the health claims, is sufficiently characterised.
2.2. Ochrona DNA, białek i lipidów przed uszkodzeniem oksydacyjnym (ID 341)
The claimed effect is “antioxidant activity”. The Panel assumes that the target population is the general population.
In the context of the proposed wordings, the Panel assumes that the claimed effect refers to the protection of body cells and molecules (such as DNA, proteins and lipids) from oxidative damage.
Reactive oxygen species (ROS) including several kinds of radicals are generated in biochemical processes (e.g. respiratory chain) and as a consequence of exposure to exogenous factors (e.g. radiation, pollutants). These reactive intermediates damage biologically relevant molecules such as DNA, proteins and lipids if they are not intercepted by the antioxidant network which includes free radical scavengers such as antioxidant nutrients.
The Panel considers that protection of DNA, proteins and lipids from oxidative damage may be a beneficial physiological effect.
3.2. Ochrona DNA, białek i lipidów przed uszkodzeniem oksydacyjnym (ID 341)
Molybdenum functions as a cofactor for some enzymes in humans, such as sulphite oxidase, xanthine oxidase (XO) and aldehyde oxidase, which are involved in sulphur amino acid and purine metabolism (IoM, 2001). None of these enzymes are recognised as belonging to the antioxidant defence system. Dietary deficiency of molybdenum has not been documented. In acquired molybdenum deficiency, uric acid levels are lowered owing to low XO activity. Uric acid can act in vivo as a radical scavenger (IoM, 2001). However, XO can also produce superoxides, contributing to increased oxidative damage.
The references provided for the scientific substantiation of this claim were general reviews and textbook information on molybdenum metabolism, function, toxicity and dietary intake in the US, but no specific data on ROS scavenging and/or protection of cells or molecules against ROS-induced damage were submitted.
The Panel considers that a cause and effect relationship has not been established between the dietary intake of molybdenum and the protection of DNA, proteins and lipids from oxidative damage.
Warunki i możliwe ograniczenia stosowania oświadczenia
Food supplement with 120μg of molybdenum in the daily dose
