ID 3161 - Dysmutaza ponadtlenkowa

PL: Dysmutaza ponadtlenkowa
EN: Superoxide dismutase (SOD)
Pdf: superoxide dismutase

Oświadczenie (2)

1. Charakterystyka żywności / składnika

The food constituents that are the subjects of the health claims are “superoxide dismutase (SOD)”, “melon extract (containing SOD)/wheat gliadin”, and “pollen pistil extract + SOD”.
Superoxide dismutases (SOD) comprise a class of enzymes that convert the superoxide anion radical into hydrogen peroxide and oxygen. The type of SOD that is the subject of the claim is not specified (amino acid sequence and mineral cofactor). However, enzymatic activity of SOD can be measured by established methods and can be used to standardise its content in foods. Gliadin is a glycoprotein present in wheat and other cereals. Gliadin is used to protect enzymes (e.g. SOD) against stomach acid-induced breakdown.
The Panel assumes that the food constituent that is the subject of the health claims (i.e. the “active” food constituent responsible for the claimed effect) is SOD. The Panel notes that absorption of intact SOD has not been observed in humans and is unlikely to occur.
The Panel considers that the food constituent, superoxide dismutase, which is the subject of the health claims, is sufficiently characterised in relation to the claimed effects.

2.2. Ochrona skóry przed uszkodzeniem promieniami ultrafioletowymi (UV) (ID 2305, 3161)

The claimed effect is “endogenous antioxidant enzyme, protects skin from sun damage”. The Panel assumes that the target population is the general population.
In the context of the proposed wordings, the Panel assumes that the claimed effect refers to UV- dependent premature aging of the skin related to photo-oxidative damage of skin structure and texture.
Skin aging and premature skin aging is related to UV-induced photo-oxidative reactions which activate matrix-metallo-proteinases that degrade extracellular matrix proteins including collagen.
The Panel considers that protection of the skin from photo-oxidative (UV-induced) damage is a beneficial physiological effect.

3.2. Ochrona skóry przed uszkodzeniem promieniami ultrafioletowymi (UV) (ID 2305, 3161)

A total of 27 references were provided for the scientific substantiation of this claim.
None of the references provided assessed the effects of SOD consumption in preventing photo- oxidative damage to the skin whereas four references assessed the protection of skin from sun damage.
Laverdet (2003) and Laverdet et al. (2005) reported on an open label, uncontrolled intervention study where Glisodin® (2 x 250 mg per day) was administered for two months to 15 adult patients (11 females) suffering from fragile skin or hypersensitivity to sun. The Panel considers that no conclusions can be drawn from this uncontrolled study for the scientific substantiation of the claimed effect.
The other two papers (Mac-Mary et al., 2005; 2007) described the same randomised, double-blind, placebo-controlled study in which 50 healthy volunteers of phototype II, III and IV were randomised to consume Glisodin® (2 x 250 mg per day) or placebo for a period of four weeks. No statistically significant differences between the intervention and placebo groups were found with respect to changes in the Minimum Erythematal Dose (MED) or in the erythemal response (reddening and vascularisation).
The Panel concludes that a cause and effect relationship has not been established between the consumption of SOD and protection of the skin from photo-oxidative (UV-induced) damage.

Warunki i możliwe ograniczenia stosowania oświadczenia

500 mg equivalent to 500 IU (NBT units) for 1 to 2 months