ID 3133 - Kwas liponowy

PL: Kwas liponowy
EN: Alpha Lipoic acid (ALA)
Pdf: alpha-lipoic acid

Oświadczenie (2)

1. Charakterystyka żywności / składnika

The food constituent that is the subject of the health claims is alpha-lipoic acid.
Alpha-lipoic acid, also known as thioctic acid, is a non-essential sulphur-containing food constituent structurally well-defined and present in foods generally bound to protein (lipoyllysine) at very low concentrations (around 0.3 mg/100 g for the richest natural sources, i.e., spinach for vegetables and kidney for meat). The natural compound is the R enantiomer, while in food supplements generally the racemic form (R/S) is used. It exists in redox forms, the oxidised form with a closed cycle containing a disulfide bond or a reduced form, with an open ring containing two thiol groups (dihydrolipoic acid). Alpha-lipoic acid is measurable in foods by established methods.
The Panel considers that the food constituent, alpha-lipoic acid, which is the subject of the health claims is sufficiently characterised.

2.5. Regeneracja genów, regeneracja transkrypcji genów, wpływ na aktywność NF-kappa beta (ID 3133)

The claimed effect is “regeneration of genes, regeneration of gene transcription and the influence to activity NF-kappa B”. The Panel assumes that the target population is the general population.
“Regeneration of genes, regeneration of gene transcription and the influence to activity NF-kappa B” is not sufficiently defined, no more details were provided in the proposed wording, and the only reference submitted (i.e., an in vitro study describing the effects of alpha-lipoic acid on the replication of the HIV-virus) was unrelated to the claimed effect.
The Panel considers that the claimed effect “regeneration of genes, regeneration of gene transcription and the influence to activity NF-kappa B” is too unspecific for a scientific evaluation.
The Panel concludes that a cause and effect relationship has not been established between the consumption of alpha-lipoic and “regeneration of genes, regeneration of gene transcription and the influence to activity NF-kappa B”.

Warunki i możliwe ograniczenia stosowania oświadczenia

150 - 450 mg daily