ID 310 - Mangan

PL: Mangan
EN: Manganese
Pdf: manganese

Oświadczenie (4)

Oświadczenie (2)

1. Charakterystyka żywności / składnika

The food constituent that is the subject of the health claim is manganese, which is a well recognised nutrient and is measurable in foods by established methods.
Manganese occurs naturally in foods and is authorised for addition to foods (Annex I of Regulation (EC) No 1925/20064 and Annex I of Directive 2002/46/EC5). This evaluation applies to manganese naturally present in foods and those forms authorised for addition to foods (Annex II of Regulation (EC) No 1925/2006 and Annex II of Directive 2002/46/EC).
The Panel considers that the food constituent, manganese, which is the subject of the health claim, is sufficiently characterised.

2.2. Utrzymanie prawidłowego stanu kości (ID 310)

The claimed effect is “bone formation”. The Panel assumes that the target population is the general population.
In the context of the proposed wording, the Panel notes that the claimed effect relates to the maintenance of normal bone.
The Panel considers that the maintenance of normal bone is beneficial to human health.

3. Naukowe uzasadnienia wpływu na zdrowie człowieka

Manganese is essential as a cofactor for the metalloenzymes superoxide dismutase (SOD), xanthine oxidase, arginase, galactosyltransferase and pyruvate carboxylase. Manganese also activates a number of other enzymes such as various decarboxylases, glutamine synthetase, hydrolases, kinases and transferases, such us glycosyltranferases. Manganese is not essential for the activity of most of these enzyme systems, which can also be activated by other metals, with the exception of glycosyltransferases (JHCI, 2003; Buchman, 2006).

3.2. Utrzymanie prawidłowego stanu kości (ID 310)

Glycosyltranferases and xylosyltransferases are important for proteoglycan synthesis and thus bone formation and are sensitive to manganese intake and status in animals (JHCI, 2003; IoM, 2001; Buchman, 2006). Manganese deficiency interferes with normal skeletal development in various animal species (Combs et al., 1942; Leach and Muenster, 1962; Tsai and Everson, 1967). The very few cases reported of manganese deficiency in humans (induced in experimental conditions) also point towards an impairment of growth and development of bone. However, manganese deficiency has not been well documented in humans (Buchman, 2006).
The Panel concludes that a cause and effect relationship has been established between the dietary intake of manganese and the maintenance normal bone. However, the evidence provided does not establish that intake of manganese inadequate for the maintenance of normal bone occurs in the general EU population.

4.2. Utrzymanie prawidłowego stanu kości (ID 310)

The Panel considers that the following wording reflects the scientific evidence: “Manganese contributes to the maintenance of normal bone”.

5. Warunki i możliwe ograniczenia stosowania oświadczenia

The Panel considers that in order to bear the claims a food should be at least a source of manganese as per Annex to Regulation (EC) No 1924/2006. Such amounts can be easily consumed as part of a balanced diet. The target population is the general population. Although adverse health effects of excess intake of manganese have been reported, Tolerable Upper Intake Levels (UL) have not been established owing to lack of data on dose response (SCF, 2000).

Warunki i możliwe ograniczenia stosowania oświadczenia

Must at least be a source of mineral/s as per annex to regulation 1924/2006