ID 2890 -
Cynk
PL: Cynk
EN: Zink
Pdf: zinc
Oświadczenie (4)
- Cynk przyczynia się do prawidłowego metabolizmu makroskładników
Oświadczenie (2)
- cynku jest element lub kofaktora różnych enzymów metabolizmu białek, węglowodanów i tłuszczów oraz kwasów nukleinowych: dehydrogenazy alkoholowej, dysmutazy ponadtlenkowej, polimerazy DNA, polimerazy RNA, fosfatazy alkalicznej, karboksypeptydazy. Jest również zaangażowany w działalność ponad 200 enzymów. jej głównym fizjologicznych skutków na wszystkich etapach syntezy białek. cynk aktywizuje polimerazy DNA i RNA i ma zasadnicze znaczenie dla regulacji histonów. jest również udział w kilku hormonów peptydowych stabilizacji (insulina, Gustin, thymulin)
1. Charakterystyka żywności / składnika
The food constituent that is the subject of the health claims is zinc, which is a well recognised nutrient and is measurable in foods by established methods. Zinc occurs naturally in foods and is authorised for addition to foods (Annex I of the Regulation (EC) No 1925/20066 and Annex I of Directive 2002/46/EC7). This evaluation applies to zinc naturally present in foods and those forms authorised for addition to foods (Annex II of the Regulation (EC) No 1925/2006 and Annex II of Directive 2002/46/EC).
The Panel considers that the food constituent, zinc, which is the subject of the health claims, is sufficiently characterised.
2.10. Udział w prawidłowym metabolizmie makroskładników (ID 2890)
The claimed effect is “zinc is an element or cofactor of various enzymes of the metabolism of proteins, carbohydrates and lipids as well as of nucleic acids: alcohol dehydrogenase, superoxide dismutase, DNA polymerase, RNA polymerase, alkaline phosphatases, carboxypeptidase. It is also involved in the activity of more than 200 enzymes. Its main physiological impact is in all steps of protein synthesis. Zinc activates DNA and RNA polymerases and is essential to histones regulation. It is also involved in several peptidic hormones stabilisation (insulin, gustin, thymulin)”. The Panel assumes that the target population is the general population. In the context of the proposed wordings, the Panel assumes that the claimed effect refers to macronutrient metabolism.
The Panel considers that contribution to normal macronutrient metabolism is a beneficial physiological effect.
3. Naukowe uzasadnienia wpływu na zdrowie człowieka -
Zinc is present in all tissues. It has essential structural, regulatory or catalytic roles in many enzymes. It maintains the configuration of a number of non-enzymatic proteins such as pre-secretory granules of insulin, some mammalian gene transcription proteins and thymulin. It facilitates hormone and receptor binding at membrane and nuclear levels, and it may maintain integrity of biomembranes. Consequently zinc participates in gene expression and in the mechanisms and control of major metabolic pathways involving proteins, carbohydrates, nucleic acids and lipids (SCF, 1993; DoH, 1991). Human zinc deficiency symptoms include retarded growth, depressed immune function, skin lesions, skeletal abnormalities, impaired reproductive ability and behavioural abnormalities such as changes in mood, loss of affect and emotional lability, anorexia, dysfunction of smell and taste, irritability and depression (SCF, 2003; EVM, 2002, Cousins, 2006).
3.8. Udział w prawidłowym metabolizmie makroskładników (ID 2890)
Zinc has essential structural, regulatory or catalytic roles in many enzymes. Many of the enzymes of the intermediate metabolism contain zinc, and deficiency affects the metabolism of all macronutrients. Protein synthesis, DNA synthesis and RNA synthesis require zinc. Lipid metabolism is also affected, with zinc deficiency being associated with reductions in circulating high-density lipoproteins (Freake, 2006; EVM, 2002; FAO/WHO 2004).
The Panel concludes that a cause and effect relationship has been established between the dietary intake of zinc and contribution to normal macronutrient metabolism. However, the evidence provided does not establish that inadequate intake of zinc leading to impaired macronutrient metabolism occurs in the general EU population.
4.7. Udział w prawidłowym metabolizmie makroskładników (ID 2890)
The Panel considers that the following wording reflects the scientific evidence: “Zinc contributes to normal macronutrient metabolism”.
5. Warunki i możliwe ograniczenia stosowania oświadczenia
The Panel considers that in order to bear the claim a food should be at least a source of zinc as per Annex to Regulation (EC) No 1924/2006. The target population is the general population. Such amounts can be easily consumed as part of a balanced diet. Tolerable Upper Intake Levels (ULs) have been established for zinc in children, adolescents, adults, pregnant and lactating woman (SCF, 2003).
Warunki i możliwe ograniczenia stosowania oświadczenia
doivent être source de minéraux au sens de l'annexe du règlement CE/1924/2006
