ID 2861 -
Mangostan właściwy
PL: Mangostan właściwy
EN: Mangosteen (Garcinia mangostana L) fruits and extracts derived from the fruits
Pdf: various food(s)/food constituent(s) not supported by pertinent human data
1.4. Utrzymanie prawidłowego stężenia cholesterolu LDL we krwi (ID 1763, 2861, 3101, 4406)
The claimed effects are “cardiovascular health”, “control of blood lipids”, and “blood cholesterol”. The Panel assumes that the target population is the general population.
In the context of the proposed wordings and the clarifications provided by Member States, the Panel assumes that the claimed effects refer to the maintenance of normal blood LDL-cholesterol concentrations.
The Panel considers that maintenance of normal blood LDL-cholesterol concentrations is a beneficial physiological effect.
2.4. Utrzymanie prawidłowego stężenia cholesterolu LDL we krwi (ID 1763, 2861, 3101, 4406)
The references provided in relation to these claims were book chapters and narrative reviews on the potential health effects of different food(s)/food constituent(s) which did not provide any original data for the scientific substantiation of the claims, addressed the effects of food(s)/food constituent(s) other than those which are the subject of the claims, and/or investigated health outcomes (e.g. resistance of LDL particles to peroxidation, liver steatosis, platelet aggregation, incidence of chronic diseases such as ischaemic heart disease, cancer, or asthma) other than blood cholesterol concentrations. The Panel considers that no conclusions can be drawn from these references for the scientific substantiation of the claims.
No human studies which investigated the effects of the food(s)/food constituent(s) on blood LDL-cholesterol concentrations were provided in relation to any of the claims evaluated in this section.
A number of animal studies which addressed the effects of some of the food(s)/food constituent(s) on the blood lipid profile, and a number of animal and in vitro studies which addressed the mechanisms by which the food(s)/food constituent(s) could exert the claimed effect were provided (e.g. activity of 3-hydroxy-3-methyl-glutaryl-CoA reductase, acyl CoA:cholesterol tranferases and/or microsomal triglyceride transfer protein in the liver). The Panel considers that evidence provided in animal and in vitro studies is not sufficient to predict the occurrence of an effect of the consumption of the food(s)/food constituent(s) on blood LDL-cholesterol concentrations in vivo in humans.
The Panel concludes that a cause and effect relationship has not been established between the consumption of the food(s)/food constituent(s) which are the subject of the claims evaluated in this section and maintenance of normal blood LDL-cholesterol concentrations.
Warunki i możliwe ograniczenia stosowania oświadczenia
Typical adult dosage: 30-100 ml daily of whole fruit juice.