ID 2505 - Kukurydza zwyczajna

PL: Kukurydza zwyczajna
EN: Zea mays (maize, corn)
Pdf: various food(s)/food constituent(s)

Oświadczenie (2)

1.4. Ograniczenie zapalenia (ID 546, 547, 641, 2505, 2862)

The claimed effects are "regulation of metabolic function", "molecule precursors regulating cell functions (prostaglandins, leucotrienes)", "supportive measure for healthy inflammatory responses", "kidneys health" and "regulation of inflammatory responses in the body". The Panel assumes that the target population is the general population.
In the context of the proposed wordings and the clarifications provided by Member States, the Panel assumes that the claimed effects refer to the reduction of inflammation.
Inflammation is a non-specific physiological response to tissue damage which is mediated by the immune system. Adequate inflammatory responses are of primary importance for the defence against injury of any origin. Changes in markers of inflammation such as various interleukins do not indicate a beneficial physiological effect per se but should be linked to a beneficial physiological or clinical outcome. The Panel considers that no evidence has been provided to indicate the context in which the claimed effect could be considered to be a beneficial physiological effect.
For ID 2862 the suppression of pro-inflammatory cytokine production (e.g. TNF-α) was mentioned in the clarifications provided, and additional inflammatory markers (e.g. prostaglandin E2,
inhibitor-kappa-B-kinase, IL-8, NFkappaB) were addressed in the in vitro studies provided for the scientific substantiation of the claim. The Panel considers that no evidence has been provided to indicate the context in which the changes in these markers could indicate a beneficial physiological effect in humans.
The Panel concludes that a cause and effect relationship has not been established between the consumption of the food(s)/food constituent(s), which are the subject of the health claims, and a beneficial physiological effect related to the reduction of inflammation.

1.5. Zwiększenie wydalania wody przez nerki (ID 2505)

The claimed effect is "kidneys health". The Panel assumes that the target population is the general population.
In the context of the proposed wording, the Panel assumes that the claimed effect refers to an increase in renal water elimination (i.e. diuresis).
Substances which force diuresis also decrease the extracellular fluid volume by increasing renal sodium and water excretion.
Under normal conditions, fluid balance is tightly regulated over a 24-h period (Subudhi et al., 2005). Water deficits and excesses trigger compensatory changes in either water gains or losses until water balance is re-established (EFSA Panel on Dietetic Products Nutrition and Allergies (NDA), 2010). A fall in intravascular volume or extracellular fluid volume will lead through a tightly regulated feedback system to increased renal tubular reabsorption of sodium and water (Shirreffs and Maughan, 2005).
Losses in body water, which are not adequately compensated, will result in dehydration.
The Panel considers that the evidence provided does not establish that an increase in renal water elimination, which could lead to a negative fluid balance, is a beneficial physiological effect for the general healthy population.
The Panel concludes that a cause and effect relationship has not been established between the consumption of the food(s)/food constituent(s), which are the subject of the health claim, and a beneficial physiological effect related to an increase in renal water elimination.

Warunki i możliwe ograniczenia stosowania oświadczenia

Extract: 10mg / Used as part of a multibotanical combination