ID 2041 - Kapsaicyna

PL: Kapsaicyna
EN: Capsicum Extract -–with Capsaicin
Pdf: capsaicin

1. Charakterystyka żywności / składnika

The food constituent that is the subject of the health claims is capsaicin.
Capsaicin (8-methyl-N-vanillyl-6-nonenamide) is a compound present in large quantities in the fruits, mainly in the pericarp, placenta and seeds of most of the species of plants belonging to the genus Capsicum. Capsaicin can be measured by established methods.
The Panel considers that the food constituent, capsaicin, which is the subject of the health claims, is sufficiently characterised.

2.1. Utrzymanie masy ciała po odchudzaniu (ID 2039, 2041, 2042)

The claimed effects are “required for enhancing thermogenesis, increasing energy expenditure and enhancing loss of calories”, “required for fat oxidation and burns fat, leading to loss in body weight”, and “required for reducing caloric intake”. The target population is assumed to be overweight individuals in the general population who wish to maintain their body weight after significant weight loss.
In the context of the proposed wordings and references provided, the Panel assumes that the claimed effects refer to the maintenance of body weight after weight loss.
Maintenance of weight loss can be interpreted as the contribution to the maintenance of a normal body weight after significant weight loss. In this context, the maintenance of weight loss in overweight subjects without having achieved a normal body weight is considered to be a beneficial physiological effect.
The Panel considers that maintenance of body weight after weight loss is a beneficial physiological effect.
6

3.1. Utrzymanie masy ciała po odchudzaniu (ID 2039, 2041, 2042)

Among the references provided for the scientific substantiation of the claim were two narrative reviews on obesity and macronutrient metabolism which did not provide any original data for the scientific substantiation of the claim. Some human studies and one animal study investigated the effects of food(s)/food constituent(s) other than capsaicin, and/or investigated health outcomes other than body weight changes (e.g. energy metabolism, lipoprotein oxidation, energy intake). The Panel considers that no conclusions can be drawn from these references for the scientific substantiation of the claim.
One reference reported on a randomised, double-blind, placebo-controlled, intervention study which investigated the effect of consuming capsaicin-containing capsules (135 mg/day of capsaicin and 1.2 g/day of vegetable oil) versus placebo capsules (1.3 g/day of vegetable oil) for three months on body weight in 120 moderately overweight subjects) (Lejeune et al., 2003). Before the 3-months intervention period (i.e. weight-maintenance period), all subjects received a very-low-energy-diet for four weeks with the aim of losing weight. A total of 23 subjects dropped out during the first four weeks of the study. Thereafter, the weight-maintenance period started and subjects were randomised to receive capsaicin-containing capsules or placebo. Six subjects were removed from the analyses as they continued losing weight or regained more than 100 % weight during the weight-maintenance period. Statistical analyses were performed on 42 subjects in the capsaicin group and 49 in the placebo group. Measurements of body weight were performed at baseline (i.e. before starting the very-low-energy-diet), and at each month up to the end of the weight-maintenance period. No significant differences between the capsaicin and placebo groups were observed at any time with respect to body weight changes. The Panel notes that this study did not show an effect of capsaicin on the maintenance of body weight after weight loss.
In weighing the evidence, the Panel took into account that the only human intervention study provided from which conclusions could be drawn for the scientific substantiation of the claim found no effect of the consumption of capsaicin on body weight maintenance after weight loss.
The Panel concludes that a cause and effect relationship has not been established between the consumption of capsaicin and maintenance of body weight after weight loss.
7

Warunki i możliwe ograniczenia stosowania oświadczenia

In the various human clinical studies the dosage of Capsaicin from Red Pepper administered at the dose of 30- mg/day In the various human clinical studies the dosage of Capsicum extract administered at the dose of 135 mg/day In the various human clinic