ID 195 -
Kwas foliowy
PL: Kwas foliowy
EN: Folate
Pdf: folate
Oświadczenie (4)
- Kwas foliowy przyczynia się do prawidłowej syntezy aminokwasów
Oświadczenie (2)
- la kwas foliowy (witamina B9) participe au mA © tabolisme des PROTA © ines
- Cell Division / mnożenie: kwasy nukleinowe i aminokwasy syntezy kwasów (np. w przewodzie pokarmowym)
1. Charakterystyka żywności / składnika
The food constituent that is the subject of the health claims is folate. Folate is measurable in foods by established methods.
Folate is the generic name for a number of derivatives of pteroylglutamic acid (PGA, folic acid). Folic acid is a synthetic folate compound used in food supplements and in food fortification because of its stability, and which becomes biologically active after reduction. Natural (dietary) folates are mostly reduced folates, i.e. derivatives of tetrahydrofolate (SCF, 2000).
Different forms of folate are authorised for addition to foods (Annex II of the Regulation (EC) No 1925/20066 and Annex II of Directive 2002/46/EC7). This evaluation applies to folate naturally present in foods and those forms authorised for addition to foods (Annex II of the Regulation (EC) No 1925/2006 and Annex II of Directive 2002/46/EC).
The Panel considers that the food constituent, folate, which is the subject of the health claims, is sufficiently characterised.
2.4. Podziały komórek (ID 195, 2881)
The claimed effects are “la folate (vitamin B9) participe au métabolisme des protéines” and “cell division/multiplication: nucleic acids and amino acids synthesis (such as in the gastrointestinal tract)”. The Panel assumes that the target population is the general population.
In the context of the proposed wording, the Panel assumes that the claimed effect refers to normal cell division.
A claim on folate and normal cell division has already been assessed with a favourable outcome (EFSA Panel on Dietetic Products Nutrition and Allergies (NDA), 2009).
2.5. Udział w prawidłowym tworzeniu aminokwasów (ID 195, 2881)
The claimed effect are “la folate (vitamine B9) participe au métabolisme des protéines” and “cell division/multiplication: nucleic acids and amino acids synthesis (such as in the gastrointestinal tract)”. The Panel assumes that the target population is the general population.
In the context of the proposed wording, the Panel assumes that the claimed effect refers to normal amino acid synthesis.
The Panel considers that contribution to normal amino acid synthesis is a beneficial physiological effect.
3. Naukowe uzasadnienia wpływu na zdrowie człowieka -
Folates play an important role in the transfer of C1-groups (i.e. methyl-, methylene- and formyl- groups), maintaining the methylation balance (SCF, 2000). Folate coenzymes are involved in numerous reactions that involve DNA synthesis, purine synthesis, generation of formate into the formate pool and amino acid interconversion (IoM, 1998).
3.4. Udział w prawidłowym tworzeniu aminokwasów (ID 195, 2881)
Folate coenzymes are involved in amino acid interconversions, including the catabolism of histidine to glutamic acid, interconversion of serine to glycine and remethylation of homocysteine to methionine (IoM, 1998; FAO/WHO, 2002; Carmel, 2006). Folate-mediated transfer of single-carbon units from serine provides a major source of substrate in single-carbon metabolism. The conversion of homocysteine to methionine serves as a major source of methionine for the synthesis of S-adenosyl- methionine, which participates as the methyl donor in many biological methylation reactions of proteins, nucleoproteins, histones, neurotransmitters and phospholipids (IoM, 1998; Carmel, 2006).
The Panel concludes that a cause and effect relationship has been established between the dietary intake of folate and contribution to normal amino acids synthesis.
4.3. Udział w prawidłowym tworzeniu aminokwasów (ID 195, 2881)
The Panel considers that the following wording reflects the scientific evidence: “Folate contributes to normal amino acid synthesis”.
5. Warunki i możliwe ograniczenia stosowania oświadczenia
The Panel considers that in order to bear the claims a food should be at least a source of folate as per Annex to Regulation (EC) No 1924/2006. Such amounts can be easily consumed as part of a balanced diet. The target population is the general population. Tolerable Upper Intake Levels (ULs) have been established for folic acid for children and adults (SCF, 2000).
Warunki i możliwe ograniczenia stosowania oświadczenia
1 comprimé par jour de façon continue à partir de 45 ans.