ID 1907 -
Naringina
PL: Naringina
EN: Naringin (a component of citrus peel extract and precursor of naringenin)
Pdf:
1.2. Utrzymanie prawidłowego stanu kości (ID 1764, 1907, 2418, 4012, 4020, 4056, 4175)
The claimed effects are "bone" and "bone health". The Panel assumes that the target population is the general population.
In the context of the proposed wordings, the Panel assumes that the claimed effects refer to the maintenance of normal bone.
The Panel considers that maintenance of normal bone is a beneficial physiological effect.
2.2. Utrzymanie prawidłowego stanu kości (ID 1764, 1907, 2418, 4012, 4020, 4056, 4175)
No intervention studies in humans investigating the effects of the food(s)/food constituent(s) on bone in healthy subjects have been provided in relation to any of the health claims evaluated in this section.
A number of in vitro studies were provided addressing the effects of different food(s)/food constituent(s) on human osteoblast/osteoclast cell lines. Also, studies were provided on the
relationship between the intake of the food(s)/food constituent(s) and the claimed effect in animal models of experimentally-induced osteoporosis. The Panel considers that the evidence provided in the animal and in vitro studies submitted is not sufficient to predict the occurrence of an effect of the food(s)/food constituent(s) on the maintenance of normal bone in vivo in humans. The Panel considers that while effects shown in animal and in vitro studies may be used as supportive evidence, human studies are required for substantiation of a claim. Thus, for claims supported by references to animal studies and/or in vitro studies only, the Panel considers that a cause and effect relationship has not been established between the consumption of the food(s)/food constituent(s) and the claimed effect.
The Panel concludes that a cause and effect relationship has not been established between the consumption of the food(s)/food constituent(s) evaluated in this section and the maintenance of normal bone.
3. Naukowe uzasadnienia wpływu na zdrowie człowieka
Most of the references provided addressed food(s)/food constituent(s) other than those for which the specific claims are proposed, and/or claimed effects unrelated to the structure and/or function of joints, bone and muscles. This literature includes general reviews on the "antioxidant" or "anti- inflammatory" properties of food(s)/food constituent(s) used in certain countries in the management of medical conditions associated with acute or chronic joint damage of either inflammatory or degenerative origin (e.g. osteoarthritis, rheumatoid arthritis, psoriatic arthritis, arthritis of infectious origin). The Panel considers that no scientific conclusions can be drawn from these references for the substantiation of the claims.
Warunki i możliwe ograniczenia stosowania oświadczenia
≥ 500 mg
(particularly suited for peri- and post-menopausal women)
