ID 181 -
Kwas pantotenowy
PL: Kwas pantotenowy
EN: Panthothenic acid
Pdf: pantothenic acid
Oświadczenie (4)
- Kwas pantotenowy przyczynia się do prawidłowej syntezy i metabolizmu hormonów steroidowych, witaminy D i niektórych neuroprzekaźników
Oświadczenie (2)
- syntezę i metabolizm hormonów steroidowych, witaminy A, D, B12 i neuroprzekaźników
1. Charakterystyka żywności / składnika
The food constituent that is the subject of the health claim is pantothenic acid (vitamin B5) which is a well recognised nutrient and is measurable in foods by established methods.
Pantothenic acid occurs naturally in foods and is authorised for addition to foods (Annex I of Regulation (EC) No 1925/20063 and Annex I of Directive 2002/46/EC4). This evaluation applies to pantothenic acid naturally present in foods and to those forms authorised for addition to foods (Annex II of Regulation (EC) No 1925/2006 and Annex II of Directive 2002/46/EC).
The Panel considers that the food constituent, pantothenic acid, which is the subject of the health claim, is sufficiently characterised.
2.8. Synteza i metabolizm hormonów steroidowych, witaminy D i niektórych neurotransmiterów (ID 181)
The claimed effect is “synthesis and metabolism of steroid hormones, vitamins A, D, B12 and neurotransmitters”. The Panel assumes that the target population is the general population.
The Panel considers that normal synthesis and metabolism of steroid hormones, vitamin D and some neurotransmitters are beneficial to human health.
3. Naukowe uzasadnienia wpływu na zdrowie człowieka
Pantothenic acid is required for the synthesis of coenzyme A (CoA), a cofactor and acyl group carrier for many enzymatic processes and for the synthesis of the prosthetic group of the acyl carrier protein (ACP), a component of the fatty acid synthesis complex. Most tissues transport pantothenic acid into cells for the synthesis of CoA (IoM, 1998). The evidence for essentiality of pantothenic acid consists of its well known role in cellular biochemistry.
Deficiency symptoms have only been observed in experimental settings such as giving a pantothenic acid metabolic antagonist and not in dietary studies. Deficiency symptoms included irritability, restlessness, fatigue, apathy, malaise, sleep disturbances, numbness and muscle cramps (IoM, 1998).
3.8. Synteza i metabolizm hormonów steroidowych, witaminy D i niektórych neurotransmiterów (ID 181)
Pantothenic acid, in the form of CoA, is required for the synthesis of isoprenoid derivatives, such as cholesterol, steroid hormones, vitamin D. Acetyl-CoA provides the essential acetyl group to the neurotransmitter, acetylcholine.
The Panel concludes that a cause and effect relationship has been established between the dietary intake of pantothenic acid and normal synthesis and metabolism of steroid hormones, vitamin D and some neurotransmitters. However, the evidence provided does not establish that inadequate intake of pantothenic acid leading to impaired synthesis and metabolism of steroid hormones, vitamin D and some neurotransmitters occurs in the general EU population.
4.3. Synteza i metabolizm hormonów steroidowych, witaminy D i niektórych neurotransmiterów (ID 181)
The Panel considers that the following wording reflects the scientific evidence: “Pantothenic acid contributes to normal synthesis and metabolism of steroid hormones, vitamin D and some neurotransmitters”.
5. Warunki i możliwe ograniczenia stosowania oświadczenia
The Panel considers that in order to bear the claim a food should be at least a source of pantothenic acid as per Annex to Regulation (EC) No 1924/2006. Such amounts can be easily consumed as part of
a balanced diet. Tolerable Upper Intake Levels have not been established for pantothenic acid in children, adolescents and adults.
Warunki i możliwe ograniczenia stosowania oświadczenia
See above