ID 1693 -
	
		
			Bioflawonoidy
		
		
		
	 
PL: Bioflawonoidy
EN: Bioflavonoids
Pdf: 
 
        
        
        
                
1.4. Flavonoids (ID 1470, 1693, 1920)  
                
                
                    The food constituents that is the subject of the claims is bioflavonoids related to the following  claimed effects: “vein health”, “antioxidant effect” and “helps maintain a healthy immune system”.   
The Panel assumes that bioflavonoids refer to flavonoids.  
Flavonoids are polyphenolic substances naturally present in vegetables and fruits, and in their  products. The group of flavonoids is large, with several hundred compounds belonging to subgroups  of flavanones, flavonols, flavan-3-ols (such as proanthocyanidins), flavonones, isoflavonoids and  anthocyanins. Proanthocyanidins are a group of flavan-3-ols ranging from dimers to polymers.  Monomeric flavan-3-ols (such as catechin and epicatechin) are not considered proanthocyanidins.  There are also differences in the linkages (A- or B-type) between the monomeric units of  proanthocyanidins. The flavonoid, including proanthocyanidin, content in different types of berries,  fruits and other plants is measurable, but the flavonoid profile varies widely depending on the food  source, and may have an impact on the claimed effects considered in this section.  
The references provided for the scientific substantiation of these claims included narrative reviews on  purified flavonoid fractions (from citrus), on quercetin and related bioflavonoids, and on  bioflavonoids in general, on various health outcomes, most of them unrelated to the claimed effects.  One systematic review on chronic venous insufficiency (CVI) patients included one trial with French 
maritime pine bark extract and one trial with grape seed extract. The Panel notes that from the  references provided it is unclear which type of flavonoids is the subject of the claims.  
The Panel considers that the food constituent, flavonoids, which is the subject of the claims, is not  sufficiently characterised in relation to the claimed effects considered in this section.  
The Panel concludes that a cause and effect relationship cannot be established between the  consumption of flavonoids and the claimed effects considered in this section.   
                 
                 
	        
        
Warunki i możliwe ograniczenia stosowania oświadczenia
 From 500 to 1000 mg