ID 1649 - Rutyna

PL: Rutyna
EN: Rutin
Pdf: rutin

Oświadczenie (2)

1. Charakterystyka żywności / składnika

The food constituent that is the subject of the health claims is rutin (quercetin-3-O-rutinoside).
Rutin is present in many plants including citrus fruits, berries and apples. A major source in the human diet is buckwheat (Fagopyrum esculentum Moench) and products made thereof. The content of rutin in food varies within a wide range up to 200-300 mg/kg. Products with rutin extracted from plant sources are available for supplementation. Rutin can be analysed by means of HPLC-UV or HPLC-MS. Rutin is cleaved in the intestine and the parent flavonoid quercetin is absorbed and metabolised in the human organism. Quercetin and its metabolites can be analysed by suitable HPLC methods.
The Panel considers that the food constituent, rutin, which is the subject of the health claims, is sufficiently characterised.

2.1. Poprawa rozszerzenia naczyń krwionośnych zależnego od śródbłonka (ID 1649, 1783)

The claimed effects are “vascular health” and “circulatory system”. The Panel assumes that the target population is the general population.
In the context of the proposed wordings and the clarifications provided by Member States, the Panel assumes that the claimed effect refers to the improvement of endothelial function.
Endothelial function is not sufficiently defined for a scientific evaluation, owing to the fact that endothelium-derived active factors play a role in the maintenance of several functions of the vascular system, including vasomotion, smooth muscle proliferation, thrombosis, inflammation, coagulation, fibrinolysis, and oxidation that can be studied by indirect methods. However, from the clarifications provided by Member States, the Panel assumes that the claimed effect refers to the role of
endothelium in increasing arterial compliance in response to an increased blood flow (i.e. endothelium-dependent vasodilation).
The Panel considers that improvement of endothelium-dependent vasodilation may be a beneficial physiological effect.

3.1. Poprawa rozszerzenia naczyń krwionośnych zależnego od śródbłonka (ID 1649, 1783)

Four references were provided for the scientific substantiation of this claim. These are an information sheet about rutin (posted on the internet in a company web site) which does not include original data, a drug manual, a narrative review of the health effects of flavonoids in general and an ex vivo study on the effects of rutin on the relaxation of arterial smooth muscle cells from rats (Fusi et al., 2003). The Panel considers that no conclusions can be drawn from these references for the scientific substantiation of the claimed effect.
The Panel concludes that a cause and effect relationship has not been established between the consumption of rutin and the improvement of endothelium-dependent vasodilation.

Warunki i możliwe ograniczenia stosowania oświadczenia

Regular consumption of rutoside via dietary sources or supplementation