ID 1602 - Glutamina

PL: Glutamina
EN: Glutamine
Pdf: L-glutamine

Oświadczenie (2)

1. Charakterystyka żywności / składnika

The food constituent that is the subject of the health claim is glutamine (as L-glutamine).
Glutamine is the most abundant naturally occurring amino acid in the human body. Dietary sources of L-glutamine include beef, chicken, fish, eggs, milk, dairy products, wheat, cabbage, beets, beans, spinach, and parsley. L-glutamine can be measured in foods by established methods.
The Panel considers that the food constituent, glutamine (as L-glutamine), which is the subject of the health claim is sufficiently characterised.

2.2. Integralność i przepuszczalność błony śluzowej jelit (ID 1602)

The claimed effect is “intestinal health”. The Panel assumes that the target population is the general population.
“Intestinal health” is not sufficiently defined. In the context of the proposed wording, the Panel assumes that the claimed effect refers to the aspects of “promoting/maintaining integrity of the intestinal lining, preventing (increased) intestinal permeability”.
Maintenance of a normal epithelial barrier in the intestines and avoidance of excess intestinal permeability is required for normal intestinal function.
The Panel considers that maintaining integrity of the intestinal lining and normal intestinal permeability is beneficial to human health.

3.2. Integralność i przepuszczalność błony śluzowej jelit (ID 1602)

Six references were cited to substantiate the claimed effect.
Two randomised placebo-controlled intervention trials in breast cancer patients receiving chemotherapy (Li et al., 2006) and in patients after portal hypertension surgery (Tang et al., 2007), respectively, were provided. The Panel notes that the evidence provided does not establish that the results of these studies can be extrapolated to the general population.
One reference reports on an experimental study in rats receiving total parenteral nutrition (Li et al., 1994), and one reference describes an in vitro study on proliferation and protein kinases in intestinal epithelial cell lines (Rhoads et al., 1997). The Panel considers that the evidence provided in the animal and in vitro studies does not predict an effect of glutamine consumption on the claimed effect in humans.
One general review of L-glutamine and a second review on glutamine and the intestinal tract were cited. The Panel notes that no scientific conclusions can be drawn from these references for the substantiation of the claimed effect.
In weighing the evidence the Panel took into account that the rat and the in vitro studies provide limited evidence to support the claimed effect in humans, and that the results of two studies in patient populations cannot be extrapolated to the general population.
The Panel concludes that a cause and effect relationship has not been established between the consumption of L-glutamine and maintaining integrity of the intestinal lining and normal intestinal permeability.

Warunki i możliwe ograniczenia stosowania oświadczenia

A stimulatory effect has been noted at high doses, some people may experience diarrhoea at high doses